Share the QR code < / P > < p > with wechat scanning code to friends and circle of friends < / P > < p > < / P > < p > surging news reporter Hu Danping < / P > < p > whether the antibody is produced after the new crown vaccine is an important indicator to test whether the vaccine can work. Many netizens on the "leadership message board" of the people's network reported that some people tested negative antibodies after playing the new crown vaccine. They did not produce antibodies. Can they have a supplementary vaccine? Recently, some scholars have suggested that antibody tests should be carried out to grasp the immune level of the crowd to COVID-19. Officials have repeatedly stated that it is not recommended that individuals carry out new crown antibody testing, which is neither necessary nor feasible < p > < / P > < p > why is it not recommended for individuals to test for new crown antibodies? What is the focus of debate between doing and not doing antibody testing? What are the technical difficulties in antibody detection to verify the protective effect of vaccine? On November 9, surging news interviewed a number of experts to answer

has reported that "no new crown antibody has been detected in personal tests".

was reported in January 20th at the press conference of the joint defense and joint control mechanism of the State Council. Some of the public after vaccination showed that they did not produce COVID-19 antibodies, and asked whether China had such a situation. p> < p > Feng Zijian, then deputy director of the China CDC, said that most people can produce antibodies after vaccination. It can also be seen from the current vaccine clinical research results that more than 97% can produce neutralizing antibodies after vaccination, which is tested with standard neutralizing antibodies under the conditions of clinical trials. However, all vaccines cannot produce 100% antibodies, because this is mainly related to individual differences < p > Feng Zijian stressed that mass vaccination is not recommended, and it is not necessary to carry out routine antibody testing for each vaccinator < p > on August 27, renmin.com reported that some netizens put forward suggestions on the leadership message board, hoping to test the antibodies of the vaccinated population as soon as possible and reseed those who did not appear antibodies after vaccination. In this regard, at the press conference of the joint prevention and control mechanism of the State Council held on the same day, Zheng Zhongwei, head of the vaccine research and development team of the scientific research group of the joint prevention and control mechanism of the State Council and director of the medical and health science and Technology Development Research center of the National Health Commission, once again stressed that antibody testing was "neither necessary nor feasible" < p > it was also on the leader message board of the people's network, which was reported by netizens on October 27 "From May to July 2021, I was vaccinated with three injections of Anhui Zhifei's new crown vaccine as planned. After that, I did the new crown antibody test in Chang'an hospital on September 28. The test result was negative and showed no antibody. In order to prevent infection with the new crown, can I apply for another vaccination? What procedures do I need? Is it free?" In response, the Xi'an municipal health and Health Committee of Shaanxi province replied that people who had completed the 3 doses of COVID-19 vaccine in Anhui did not need to enhance immunity. Whether

had antibody detection problems remained controversial. Whether

produced antibodies after vaccination is an important indicator of whether the vaccine is effective or not. Many people also care about the antibody level because of this reason.

, in fact, There is such an operation in the vaccination of hepatitis B. According to the recommendation of China's guideline for chronic hepatitis B prevention, the general population does not need to carry out anti -HBs (hepatitis B surface antibody). Monitoring or strengthening immunization, but for high-risk groups or immunocompromised persons, etc. can monitor the anti -HBs, such as hepatitis B surface antigen quantitative < 10 mlU/mL, can be vaccinated with 1 needle hepatitis B vaccine.

a university immunologist told surging news, personal detection of COVID-19 antibody to verify the vaccine effect should be an essential item. Another university virologist believed that inoculation. It is a fact that the antibody level of the live vaccine dropped sharply after March, which is true for the vast majority of people, so it is of little significance not to detect the antibody. < / P > < p > in an interview with surging news on November 9, Chang Rongshan, a virologist at Shantou University, said that when someone tested IgG antibody after vaccination, the result was negative, which does not necessarily mean that he did not produce antibody, but it is related to the design of the antibody kit itself Guan. Chang Rongshan once obtained three invention patents for colloidal gold reagents. He believes that if the existing approved fast test cards for detecting neutralizing antibodies produced by natural infection are used for large-scale antibody detection, because these kits are not designed for neutralizing antibodies produced after vaccination with the new crown vaccine, there may be a large number of false negatives, which is easy to cause panic< /p> < p > "in the past, normal vaccines did not carry out antibody testing for people, and there were no legal requirements in this regard, so we think it is not necessary to carry out." Zheng Zhongwei also stressed that to judge whether a vaccine is effective or not, it is mainly through the preliminary clinical trials and the real-world research based on the large-scale epidemic situation in the later stage, rather than simply judging whether the vaccine is effective and can be protected by a neutralizing antibody level. Therefore, at this stage, it is not necessary to carry out large-scale population-based research Another expert from the field of epidemiology also believes that antibody testing is mainly used for vaccine evaluation research and population immune status sampling survey. Generally, it is not necessary to carry out the test of the success of individual post vaccination immunization. For some professionals with particularly high risk of exposure to infection, neutralizing antibody testing may be carried out during vaccination. < / P > < p > anti physical examination The technical problem of testing remains to be solved < / P > < p > what method to use to detect antibodies is the focus of debate at present. The officially recognized antibody testing is to verify the effectiveness of the vaccine by neutralizing antibody test in P3 laboratory. < / P > < p > at present, most of the antibody testing used by many people are IgM and IgG antibody testing reagents. < / P > < p > according to the letter of the State Food and Drug Administration replying to the proposal of CPPCC members on August 27 this year Information shows that by the end of June 2021, the State Food and drug administration has approved 27 antibody testing reagents, and the daily production capacity of antibody testing reagents is 16.46 million. < / P > < p > according to the information released by the State Food and drug administration, the current antibody testing reagents include IgM and IgG antibody testing reagents, mainly using colloidal gold method and magnetic particle chemical luminescence method. Due to its limitations, the new crown antibody testing is currently approved The intended use of the kit is only used as a supplementary test indicator for suspected negative cases in COVID-19 nucleic acid detection or in the diagnosis of suspected cases. In conjunction with nucleic acid detection,

"if we want to detect neutralizing antibodies produced by inactivated new crown vaccine, we must design a vaccine kit for vaccine antigens." Chang Rongshan said that at present, the antibody detection kits on the market can not ensure 100% accurate detection of neutralizing antibodies after vaccination with the new crown vaccine. More importantly, there is no public antibody ?
2023-03-22 10:04:46